In the end, yes. That’s why you read a lot of threads in Mercedes forums in Germany where people are not happy with their aftermarket setups where they used LOCs.
Basically no shop in Germany that I know uses LOCs in BMWs or Mercedes with MOST controlled systems anymore. If it's not MOST controlled people use the HELIX Match amplifiers with enough inputs and sophisticated DSPs built into them to clean up the system, but not LOCs (well, technically they are using LOCs as these are builtin into all DSPs on the market afaik).
edit due being in front of my computer now and not typing via smartphone keyboard.
It's basically the same with almost every other upgraded stock system. Look at Hyundai f.e. You need a very sophisticated DSP to overcome the allpass filters and response on the output of the stock amplifier. Or you go with an optical signal integration, which provides a flat, unaltered signal. But in this case you need the ability to control the volume of the DSP via CAN-Bus f.e. Anyway, a Kicker Keylock will never be able to integrate correctly after the stock amplifier.
Look at Ford A2B bus. To get rid of Active Noise Cancellation in these systems, you need some kind of integration device for the A2B-bus instead of using LOCs after the stock amplifier.
Anyway... for the upgraded stock system in 99% of all cases you want some form of integration before the stock amplifier, just to get a clean signal. And the old technology of LOCs is just not doing this anymore.
If you got a basic system without a stock amplifier and only front/rear output, then maybe yes, but still i would always check first if there is a way to reprogramm the headunit to variable line output in these cases just to prevent the need of a LOC.
But that's just me. I never understand people using Line Output Converters if there are much better ways to integrate.