Need Detailed Suggestions - 1996 Chevy Tahoe 2 Door

I recently purchased a 1996 Chevy Tahoe 2 Door from my grandfather's estate. the vehicle is in really good shape for being 20 years old. It has nothing of note in the audio department. The vehicle has the separated HU and CD player. It also has the stock 6.5's in the door and the horrendous 4x10's in the back headliner. I would love to upload pictures of my vehicle, but I have not reached the post count yet. As a frame of reference, Darth SQ is slowly finishing a rather phenomenal build on a relatively similar vehicle. I can't post a link to his build yet either. I will change both of these issues as soon as the post count has been reached. In any case, his vehicle, minus the 2nd row of seats and doors , is nearly identical to mine. As much as I would love to put that much quality into my vehicle, I simply do not have the time to invest in such an outstanding project. That being said, I would still like to make my vehicle competent.

After that excessive tangent, to the meat and potatoes of the post. I am happy to do as much research as possible on all situations and setups conceivable, but I want to make sure I am understanding things correctly. I would like suggestions or opinions as to what would work best in my vehicle.

I would like to use AudioFrog for the front stage. I am unsure if 2 or 3-way setup would be best. I doubt I will use anything in the back, maybe just something running off of the HU as back fill. I want to remove the spare tire, jack assembly, and plastic components in that area and use that space to build a box for my sub. I need at least half of the cargo area open for daily use. I am again unsure of sealed vs ported or a single vs dual 10" or 12" setup. I would like to incorporate an MS-8 in the system. I also plan on converting the dash from the stock to a double din setup. Any suggestions on HUs? I see that Arc, PPI, JL, Zed, Masconi, and so on and so on. I intend on doing sound deadening throughout the vehicle.

I welcome any and all suggestions and opinions.