I ran a dedicated negative run from the battery to the trunk. 2006 Toyota Solara. I regained almost a volt at the back. Interior lights became brighter, tail lights became brighter. Initially I just used the dedicated negative run for the electronics. After a stern lecture from Chad,

, Who pointed out what he mentions above, I changed the configuration. I tied the dedicated run to the chassis at 3 points. Where the battery was connected up front, in the car interior under the seat and at the initial grounding point in the trunk where my ground distribution is tied to. It made a difference that was visibly noticeable. As well as measurable. It didn't break my wallet as I used Knu oversized 1/0 CCA.
The nice thing is, it is an easy check to see if it will help. Get a length that runs front to rear outside the vehicle and just take some measurements with and without at various volume levels. See if there is voltage drop with and without. Is there noise? Is there less noise?
While yes sheet metal of a body should have enough current carrying capacity to be enough, it also has more resistance,Add in that as the metals heat up, the steel will have even more resistance. Add in that the steel used is high carbon (usually) and can have inperfections in the chemistry at different points that may not cause a weakness but certainly can affect shortest path. There is another affect called drift or something that is based on the geometry of the conductor. Can't remember the exact term.
Now does all that mean using the steel body as the negative run from the battery is bad? In almost all circumstances in a vehicle probably not. But add in high current usage audio equipment and the perpetual pursuit of sonic nirvana or the output equivelent of a bomb, and then maybe, it's not.
That's why I tried what I did and it worked for me. Your vehicle/install may not need it.