I understand, I didnt really clarify. OEM just bolts the alternator to the engine thus grounding it through the iron (older engines or larger high power engines normally) or aluminum block to the battery negative from there. I dont recommend running a ground cable from the amp to the battery though either. Thats a great way to destroy your battery. The body, frame, subframe work as great buffers for any type of power spikes which will occur from I high power amp. Also, even though the metal of the car isnt as highly conductive as a copper or aluminum cable, given the amount of metal, there is no larger gauge than an entire car. My batteries are expensive and so is my new alternator, the last thing I want to do is put them at risk or cause premature deterioration. Theres a reason that all car amplifier manuals (at least those Ive seen) say geound to the car.
Probably the best bet is just help out the car conductivity. It'll help the engine run smoother, can increase performance, and improve an amplifier which is correctly grounded.
I added multiple 4 gauge ground points from the battery to the block, manifold, body, and frame. If you search online thers a good deal of point were you can connect different grounds. The spark plugs will love it and I noticed a difference in the engine immediatly. Also, its a good idea to run a couple of large gauge (short as posssible) cables underneath between the body and the frame of the vehicle. Of course I do mean %100 copper. Oxygen free isnt that big of a deal, but tinned will probably help given the environments that those extra grounds will be connected to.
Its minimal work and cost to improve the overall life and performance of the entire vehicle and electrical components. I did all this before my stereo system was even a thought, just to insure my engine and components were running as smoothly and proficiently as possible.
Sorry, went on a tangent, but I read about the comment on connecting the ground directly to the battery. I like my audio system but it would be pointless to me if it was causing my engine to misfire due to a current change or cause the early demise of my battery, alternator, or any other aspect of the electical systems.
On a lighter note, easieat way to tell if you have ground problems, when you open or close the door from the outside and you constantly get shocked?.